Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering

Abstract Complex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, vasculature using materials that facilitate regeneration have been ongoing for decades. However, possess the mechanical, chemical, resorption characteristics necessary recapitulate these difficult mimic synthetic resorbable biomaterials. Herein, we report a series of elastomer-like compositionally identical varying ratios cis : trans double bonds in backbone. These features afford concomitant control over mechanical surface eroding degradation properties materials. We show can be functionalized post-polymerization with bioactive species enhance cell adhesion. Furthermore, an vivo rat model demonstrates dependent on succinate stoichiometry elastomers results limited inflammation highlighting their potential use soft tissue drug delivery.